Therapeutic Effect of Continuous Exercise Training Program on Serum Creatinine Concentration in Men with Hypertension: A Randomized Controlled Trial

Background: Creatinine (Cr) has been implicated as an independent predictor of hypertension and exercise has been reported as adjunct therapy for hypertension. The purpose of the present study was to investigate the effect of continuous training programme on blood pressure and serum creatinine concentration in black African subjects with hypertension. Methods: Three hundred and fifty seven male patients with mild to moderate (systolic blood pressure [SBP] between 140-180 et diastolic blood pressure [DBP] between 90-109 mmHg) essential hypertension were age matched and randomly grouped into continuous et control groups. The continuous group involved in an 8 weeks continuous training (60-79 HR reserve) of between 45minutes to 60 minutes; 3 times per week; while the control group remain sedentary. SBP; DBP; VO2max; serum Cr; body mass index (BMI); waist hip ratio (WHR) and percent () body fat. Analysis of covariance (ANCOVA) and Pearson correlation tests were used in data analysis Results: Findings of the study revealed significant decreased effects of continuous training programme on SBP; DBP; Cr; BMI; WHR; body fat and significant increase in VO2max at p 0.05. Serum Cr is significantly and negatively correlated with SBP (-.335); DBP (.194); BMI (.268); WHR (-.258) and body fat (-.190) at p0.05. Conclusion: The present study demonstrated a rationale bases for the adjunct therapeutic role of moderate intensity continuous exercise training as a multitherapy in the down regulation of blood pressure; serum Cr; body size and body fat in hypertension

Effects of Aerobic Exercise Training on Psychosocial Status and Serum Uric Acid in Men with Essential Hypertension: A Randomized Controlled Trial

Chronic psychosocial stress and serum uric acid (SUA) level have been implicated in the etiology and cardiovascular events risk factors in hypertension. Studies have reported significant benefit of exercise in the overall management of hypertension. However; studies on the effect of exercise on psychosocial stress and SUA in the management of hypertension seem scanty. Aim: The aim of this study was to determine the effect of continuous training program on SUA and psychosocial status of black African (Nigerian) population with hypertension. Subjects and Methods: Age-matched randomized controlled trial was used; subjects with diagnosis of hypertension attending the hypertensive clinic of Murtala Muhammed Specialist Hospital (MMSH); Kano; Nigeria form the population for the study. Two hundred and seventeen subjects with mild to moderate (systolic blood pressure (SBP) between 140 and180 and diastolic blood pressure (DBP) between 90 and 109 mmHg) essential hypertension were grouped into continuous (112) and control groups (105). The continuous group involved in an 8 weeks continuous training (60-79 HR max) of between 45 and 60 min; 3 times per week; while the controls group remain sedentary. SBP; DBP; SUA; VO 2 max and psychosocial status were assessed. Student t-test and Pearson correlation test were used in data analysis. Results: The study revealed significant beneficial effect of continuous training programs on VO 2 max; SBP; DBP; SUA; and psychosocial status (P 0.05). Psychosocial status and SUA was significantly and positively and negatively correlated respectively with VO 2 max at P 0.01. Conclusions: This study concludes and supports the recommendations of moderate intensity (continuous) training program in blood pressure reduction; SUA and psychosocial stress management in hypertension